Somatuline Autogel

Somatuline Autogel

lanreotide

Manufacturer:

Ipsen

Distributor:

DCH Auriga - Healthcare
Concise Prescribing Info
Contents
Lanreotide acetate
Indications/Uses
Acromegaly when the circulating levels of growth hormone & IGF-1 remain abnormal after surgery &/or radiotherapy or for whom surgery &/or radiotherapy is not an option. Clinical symptoms associated w/ acromegaly. Clinical symptoms of carcinoid tumours. Grade 1 & a subset of grade 2 (Ki67 index up to 10%) gastroenteropancreatic neuroendocrine tumours (GEP-NETs) of midgut, pancreatic or unknown origin where hindgut sites of origin have been excluded, in adult patients w/ unresectable locally advanced or metastatic disease.
Dosage/Direction for Use
SC Acromegaly 60-120 mg every 28 days. Carcinoid tumors Initially 90 mg every 28 days for 2 mth. Gastroenteropancreatic neuroendocrine tumors 120 mg every 28 days.
Contraindications
Hypersensitivity to somatostatin or related peptides.
Special Precautions
May reduce gallbladder motility & lead to gallstone formation. Inhibited secretion of insulin & glucagon. Blood glucose levels should be monitored when treatment is initiated, or when the dose is altered. Adjust antidiabetic treatment accordingly. Slight decreases in thyroid function in acromegalic patients. Thyroid function tests are recommended where clinically indicated. Monitor vol of pituitary tumour in acromegalic patients & patients presenting w/ primitive thyrotropic adenoma. Risk of decreased heart rate. Risk of sinus bradycardia in patients w/ pre-existing cardiac disorders. Caution should be taken when initiating treatment in patients w/ bradycardia. May impair ability to drive or operate machinery. Pregnancy & lactation.
Adverse Reactions
GI disorders (diarrhea & abdominal pain), cholelithiasis & inj site reactions (pain, nodule & induration).
MIMS Class
Trophic Hormones & Related Synthetic Drugs
ATC Classification
H01CB03 - lanreotide ; Belongs to the class of antigrowth hormone. Used in hypothalamic hormone preparations.
Presentation/Packing
Form
Somatuline Autogel prolonged-release soln for inj 120 mg
Packing/Price
0.5 mL x 1's
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